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Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial

The results showed that while both methods are effective, sublingual vitamin B12 is actually more efficient in raising b12 levels than injections , especially in patients with very low levels

It was also repoded that approximatedly 1% of diabetic patients have this mutation

It can be safely used for up to 30 days after opening, as long as its stored properly

But in this space, the more common pattern is stacking to compensate for weak evidence, not stacking because combination efficacy is proven